Faculty

Pathology Informatics Core FacultyCollaborating Faculty


Dmitriy Shin, PhD, MSc

Assistant Professor
Director, Division of Pathology Informatics

Education

  • Ph.D., Biomedical Informatics, University of Missouri
  • M.Sc., Computer Science, Moscow State Academy of Computer Science and Engineering

Academic Appointments

  • Assistant Professor, Translational and Cancer Bioinformatics, Department of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO
  • Pathobiology Doctoral Faculty, Pathobiology Area PhD Program, Veterinary School, University of Missouri, Columbia, MO
  • Core Faculty, MU Informatics Institute, Graduate Studies, University of Missouri, Columbia, MO

Administrative Appointments

Director of Pathology Informatics/IT, Department of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO

Research Description

Dr. Shin studies computational methods in biomedicine. He leads the Translational and Cancer Bioinformatics laboratory in MU School of Medicine, supervising PhD students and posdoctoral fellows. His primary research area is advanced computerized inference methods in personalized medicine. In his most recent work, Dr. Shin introduced the field of computational morphoproteomics in which visual patterns of protein expression from WSI immunohistochemical studies are used to infer complex interplay of signal transduction pathways to design effective combinatorial therapies for theranostics.

Dr. Shin has also been leading the Informatics/IT division of MU Pathology and Anatomical Sciences department for over 10 years. Under his leadership, new computer systems have been designed, implemented and supported, including ANA, flow cytometry, bone marrow, molecular pathology laboratory information systems and biorepository software, pathology digital dictation system, and high definition microscopy telepathology system. He has been involved in many aspects of PAS department operations, including outreach medical examiners services, and development of electronic teaching materials for anatomy and pathology education.

Recently Dr. Shin has established Whole Slide Image Analytics laboratory, which provides services for researchers and medical practitioners. WSI lab members are currently developing online WSI hematopathology and histology atlases in collaboration with Dr. Richard Hammer, MD , Dr. Donald Doll, MD and Dr. Krause, PhD.

Interests

  • translational bioinformatics
  • personalized medicine
  • computational cancer biology
  • knowledge-driven imaging informatics
  • whole slide image analytics
  • machine learning, data mining and computational intelligence

Representative Publications

  • Shin D*, Arthur G, Popescu M, Korkin D, Shyu C, Uncovering influence links in molecular knowledge networks to streamline personalized medicine. J Biomed Inform (2014), http://dx.doi.org/10.1016/j.jbi.2014.08.0034
  • D. Shin, E. Rogatsky, A. Stoyanov, “Simultaneous monitoring of multiple transitions in mass spectrometric analysis improves limit of detection for low abundance substances in complex biological samples.” J Chromatograph Separat Techniq 4: 206. doi:10.4172/2157- 7064.1000206, 2014
  • Chen Z, Shin D, Chen S, Mikhail K, Hadass O, et al. (2014) Histological Quantitation of Brain Injury Using Whole Slide Imaging: A Pilot Validation Study in Mice. PLoS ONE 9(3): e92133. doi:10.1371/journal.pone.0092133
  • Orr Hadass, Brittany N. Tomlinson, Major Gooyit, Shanyan Chen, Justin J. Purd, Jennifer M. Walker, Chunyang Zhang, Andrew B. Giritharan, Whitley Purnell, Christopher R. Robinson, Dmitriy Shin, Valerie A. Schroeder, Mark A. Suckow, Agnes Simonyi, Grace Y. Sun, Shahriar Mobashery, Jiankun Cui, Mayland Chang, Zezong Gu, “Selective Inhibition of Matrix Metalloproteinase-9 Attenuates Secondary Damage Resulting from Severe Traumatic Brain Injury.”, PLOS One, 2013, 8:10
  • D. Shin*, G. Arthur, C. Caldwell, M. Popescu, M. Petruc, A. Diaz-Arias, and C. Shyu, “A pathologist-in-the-loop IHC antibody test selection using the entropy-based probabilistic method,” Journal of Pathology Informatics, vol. 3, no. 1, p. 1, 2012.
  • Multi-resolution tile-based follicle detection using color and textural information of follicular lymphoma IHC slides Han J., Shin D., Arthur G., Shyu C., BIBM, 2010

Richard D. Hammer, MD

Associate Professor of Clinical Pathology, Pathology and Anatomical Sciences

Education

  • B.S. Pharm. Magna Cum Laude, Duquesne University
  • M.D. Medical University of South Carolina

Additonal Study

  • Pharmacology, post graduate studies, Medical University of South Carolina
  • Medical Scientist Training Program, Medical University of South Carolina
  • Resident in Pathology - Vanderbilt University Medical Center
  • Hematopathology Fellowship, Vanderbilt University Medical Center Hematology/Molecular Diagnostics Fellowship, Vanderbilt University Medical Center Fellowship in Anti-aging and Regenerative Medicine

Academic Appointments

  • Associate Professor of Clinical Pathology and Anatomic Sciences
  • Director of Hematopathology and Coagulation
  • Assistant Medical Director, Diabetes Lab

Research Description

Development of cellular therapies and diagnostic testing in metabolism and hematology.

Interests

  • stem cells
  • leukemia/lymphoma
  • epigenetics
  • nutritional medicine
  • diabetes
  • aging
  • translational research

Representative Publications

  • Hammer, RD, Collins RD, Ebrahimi S, Casey TT: Rapid immunocytochemical analysis of acute leukemias. American Journal of Clinical Pathology 1992; 97:876-884. Gross AS, Thompson FL, Arzubiaga C, Ellis D, Graber S, Hammer RD, King LL. Heparin-associated thrombocytopenia and thrombosis (HATT) presenting with livedo reticularis. International Journal Dermatology 1993; 32(4): 276-79.
  • Hammer RD, Sukpanichnant S, Casey TT, Collins RD. Rapid immunocytochemical analysis of acute leukemias: further observations. Applied Immunohistochemistry 1994; 2(2): 113-122.
  • Hammer RD, Glick AD, Greer JP, Collins RD, Cousar JB. Splenic marginal zone lymphomas: A distinct B-cell neoplasm. Am J Surg Pathol; 1996;20(5):613-626
  • Macon WR, Hammer RD, Glick AD, Collins RD, Cousar JB. Natural killer-like T-cell leukemia/lymphoma: aggressive CD56+ peripheral T-cell lymphomas of large granular lymphocytes, possibly arising from extrathymically differentiated T cells. Blood 1996; 87(4):1474-83
  • Hammer RD, Scott M, Shahab I, Casey TT, Cousar JB, Macon WR. Latent membrane protein antibody reacts with normal hematopoietic precursor cells and leukemic blasts in tissues lacking Epstein-Barr virus genome by polymerase chain reaction. Am J Clin Path 1996; 106(4):469.
  • Hammer RD, Cousar JB, Collins RD, Vnencak-Jones CL. BCL-1 gene rearrangements in paraffin-embedded tissue. Am J Clin Path (letter) 1996; 105(6). 806.
  • Hammer RD, Vnencak-Jones CL, Glick AD, Kinney MC. Microvillous lymphomas are B-cell neoplasms that frequently express CD56. Mod Pathol 1998; 11(3):239-46.
  • Shipley WR, Hammer RD, Macon WR, Lennington WJ. Characterization of CD56 (NCAM) in paraffin-embedded tissue: A potentially useful marker for neuroendocrine neoplasms and peripheral nerve. Applied Immunohistochemistry.
  • Miranda, RN, Cousar, JB, Hammer RD, Collins, RD, Vnencak-Jones, CL. Somatic mutation analysis of IgH variable regions reveals that tumor cells of most parafollicular (monocytoid) B-cell lymphoma, splenic marginal zone B-cell lymphoma, and some hairy cell leukemia are composed of memory B lymphocytes. Human Pathology, 30(3):306-312, (Mar 1999).
  • Miranda RN, Briggs RC, Kinney MC, Veno PA, Hammer RD, Cousar JB. Immunohistochemical detection of cyclin D1 using optimized conditions is highly specific for mantle cell lymphoma and hairy cell leukemia. Mod Pathol, 2000; 13(12): 1308-14.

Emily Coberly, MD

Assistant Professor of Clinical Pathology, Pathology and Anatomical Sciences

Education

  • Medical School: University of Missouri School of Medicine
  • Residency: University of Missouri Health Care
  • Fellowship: Vanderbilt University Medical Center

Interests

  • Medical student education
  • Informatics

Ilker Ersoy, PhD

Postdoctorate Fellow, Pathology and Anatomical Sciences

Education

  • Ph.D., University of Missouri College of Engineering
  • M.S., Control and Computer Engineering, Istanbul Technical University, Turkey

Interests

  • Image and Video Analysis
  • Computer Imaging
  • Informatics


Collaborating Faculty